The effect of loratadine in exercise-induced asthma.
نویسندگان
چکیده
AIMS To assess the effect of loratadine in exercise induced asthma. METHODS Randomised, double blind, placebo controlled study of 10 mg oral loratadine, once daily for three days in 11 children. At the end of the treatment period FEV(1) was measured, and patients were exercised on a treadmill. FEV(1) measurements were repeated at intervals after exercise. RESULTS Loratadine significantly reduced the decrease in FEV(1) after exercise at two, five, 10, 15, and 30 minutes, compared with placebo (p < 0.05). However, the mean decrease in FEV(1) at five minutes was more than 15% of baseline in the loratadine group. CONCLUSIONS Loratadine reduces, but does not prevent, exercise induced asthma in children.
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عنوان ژورنال:
- Archives of disease in childhood
دوره 86 1 شماره
صفحات -
تاریخ انتشار 2002